The submucosal plexus works closely with the [myenteric plexus](https://en.wikipedia.org/wiki/Myenteric_plexus), another major component of the enteric nervous system located between the layers of the muscularis externa. While the submucosal plexus primarily regulates secretion and blood flow, the myenteric plexus coordinates [gut motility]. The two plexuses communicate through interneuronal connections, ensuring coordinated activity across the different layers of the gut wall.
