Huntington’s disease is a neurodegenerative disorder caused by an abnormal expansion of CAG repeats in the HTT gene. This mutation results in the production of a mutated form of huntingtin protein, which is toxic to neurons. The disease is characterized by motor dysfunction, cognitive decline, and psychiatric symptoms. Histological studies of brains affected by Huntington’s disease reveal the presence of neuronal inclusions, which are aggregates of the mutated huntingtin protein.
