Histological grading refers to the evaluation of the degree of cellular differentiation and the extent of cell proliferation in a tissue sample. This process is crucial for diagnosing and determining the prognosis of various diseases, especially cancers. The grading system often ranges from Grade 1 to Grade 4, with Grade 1 representing well-differentiated cells that closely resemble normal tissue, and Grade 4 representing poorly differentiated cells that appear very abnormal.
