ARF6 dependent endocytosis is a cellular process mediated by the small GTPase protein ARF6 (ADP-ribosylation factor 6). It plays a crucial role in the internalization and trafficking of plasma membrane proteins and lipids, influencing various cellular functions such as cell migration, adhesion, and signaling. This pathway is distinct from the well-known clathrin-mediated endocytosis and involves unique machinery and regulatory mechanisms.