What Histological Techniques are Used to Study Metastasis?
Histological techniques are invaluable in studying cancer metastasis. Common methods include:
1. Hematoxylin and Eosin (H&E) Staining: This basic staining technique helps identify cellular and tissue structures, making it easier to locate metastatic cells in tissue sections. 2. Immunohistochemistry (IHC): This technique uses antibodies to detect specific proteins expressed by cancer cells, aiding in the identification of metastatic sites. 3. In Situ Hybridization (ISH): ISH helps detect specific nucleic acid sequences, providing insights into genetic changes associated with metastasis. 4. Fluorescence Microscopy: This advanced technique allows for the visualization of cancer cells and their interactions with the microenvironment in greater detail.
