What Histological Features are Common in Autoimmune Disorders?
Despite the diversity of autoimmune disorders, several histological features are common across different diseases:
Inflammation: This is a hallmark of autoimmune diseases. Lymphocytes, macrophages, and plasma cells typically infiltrate the affected tissues. Tissue Damage: Autoimmune reactions can lead to the destruction of normal tissue architecture. In Rheumatoid Arthritis, for example, there is erosion of cartilage and bone. Fibrosis: Chronic inflammation often leads to fibrosis, where normal tissue is replaced by scar tissue, compromising function.
