The histological effects of autoimmune disorders vary depending on the target organ:
Joints: In Rheumatoid Arthritis, the synovial membrane becomes inflamed and proliferates, leading to joint destruction. Skin: Conditions like Lupus can cause a characteristic rash and histologically show immune complex deposition at the dermal-epidermal junction. Nervous System: In Multiple Sclerosis, demyelination caused by immune-mediated attack on myelin sheaths is a key feature.
