Dysregulation of CDT1 can lead to several cellular and physiological anomalies. Overexpression of CDT1 can cause re-replication, leading to DNA damage and genomic instability. This instability is a hallmark of many cancers, suggesting that CDT1 must be tightly regulated to prevent oncogenesis. Conversely, insufficient CDT1 activity can result in incomplete DNA replication, leading to cell cycle arrest and potential cell death.
