What Histological Changes Occur with Thiamine Deficiency?
Histologically, thiamine deficiency can lead to several pathological conditions. In the nervous system, deficiency can cause [neuronal](href) degeneration, characterized by neuronal loss, gliosis, and demyelination. In severe cases, it can result in Wernicke's encephalopathy, which shows hemorrhagic lesions in specific brain regions. Other tissues, like cardiac and skeletal muscles, can also exhibit histological signs of degeneration and fibrosis due to impaired energy metabolism.
