Multiple sampling is crucial for several reasons: - Heterogeneity: Tissues such as tumors can be heterogeneous, meaning that different regions may exhibit varied pathological features. By sampling multiple areas, the histologist can ensure that the analysis captures this diversity. - Diagnosis and Staging: In diseases like cancer, accurate staging is paramount. Multiple samples can provide a clearer picture of how extensive the disease is. - Quality Control: Ensuring that the samples are representative helps in maintaining high standards of diagnostic accuracy.