What Histological Changes Are Observed in Depression?

In the context of depression, histological studies have revealed alterations in the density and morphology of neurons and glial cells in various brain regions. The hippocampus, a region critical for memory and emotion, often shows a reduction in the number of neurons and glial cells. This reduction is associated with decreased levels of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), which are essential for neuron survival and plasticity.