What Happens When Osteoblast Function is Impaired?
Impaired osteoblast function can lead to various bone disorders. For example, in osteoporosis, the balance between bone formation and resorption is disrupted, resulting in decreased bone density and increased fracture risk. In osteopetrosis, defective osteoclast function leads to excessive bone formation by osteoblasts, causing abnormally dense and brittle bones. Understanding the role of osteoblasts in these conditions is crucial for developing targeted therapies.
