Several internal and external factors can compromise the integrity of the dermal barrier:
- Aging: With age, the skin becomes thinner and more susceptible to damage. The production of collagen and elastin decreases, leading to reduced elasticity and resilience.
- Environmental Stressors: Exposure to UV radiation, pollution, and harsh weather conditions can damage the skin barrier. UV radiation, for example, can cause DNA damage and oxidative stress.
- Chemical Exposure: Harsh chemicals in skincare products, detergents, and industrial solvents can strip the skin of its natural lipids, weakening the barrier.
- Medical Conditions: Disorders such as eczema, psoriasis, and ichthyosis affect the skin's ability to function as a barrier. These conditions are often associated with genetic mutations that impair skin barrier proteins.
