Protein Folding: It acts as a chaperone protein, assisting in the proper folding of other proteins. Signal Transduction: FKBP12 is involved in the regulation of several signaling pathways, including the TGF-β and mTOR pathways, which are crucial for cell growth and differentiation. Immunosuppression: When bound to FK506 or rapamycin, FKBP12 inhibits the activity of calcineurin, an enzyme critical for T-cell activation, thus preventing immune response.
