What Experimental Models are Used to Study Mutant Huntingtin?
Various experimental models are employed to study mHTT, including transgenic animals, cell culture systems, and induced pluripotent stem cells (iPSCs). Transgenic mice expressing mutant huntingtin exhibit many of the histological and behavioral features of Huntington's disease, making them valuable for research. Cell culture models, including neuronal cell lines and primary neurons, allow for detailed cellular and molecular analyses. iPSCs derived from patients provide a human-based model to study the disease in vitro.
