How is Mutant Huntingtin Visualized in Histological Studies?
Histological techniques such as immunohistochemistry (IHC) and immunofluorescence are commonly used to visualize mHTT. Specific antibodies against huntingtin are employed to detect its presence in tissue sections. The inclusion bodies formed by mutant huntingtin can be stained with various markers, allowing for the identification of affected cells. Additionally, electron microscopy provides detailed images of these aggregates at the ultrastructural level.
