The establishment of cell polarity involves multiple steps:
1. Cytoskeleton Organization: The cytoskeleton, comprising microtubules, actin filaments, and intermediate filaments, plays a pivotal role in defining cell polarity. 2. Polarity Complexes: Key protein complexes like the Par complex (Par3, Par6, and aPKC), Scribble complex, and Crumbs complex are essential for polarity. 3. Cell-Cell Adhesion: Adhesion molecules such as cadherins and integrins help in maintaining the polarized state by mediating cell-cell and cell-matrix interactions.
