What Diseases are Associated with TDP-43 Aggregation?
The most well-known diseases associated with TDP-43 aggregation are ALS and FTLD. In ALS, TDP-43 aggregates are found in motor neurons, leading to their degeneration. In FTLD, these aggregates are found in the frontal and temporal lobes of the brain, leading to cognitive and behavioral impairments. Additionally, TDP-43 pathology has been observed in other conditions like Alzheimer's disease and Chronic Traumatic Encephalopathy (CTE).
