What are the Histological Characteristics of TDP-43 Pathology?
In histological sections, TDP-43 pathology is characterized by the presence of cytoplasmic inclusions, loss of nuclear TDP-43, and sometimes the presence of dystrophic neurites. These inclusions can be stained using TDP-43 antibodies, which typically reveal a granular or filamentous appearance. The inclusions are often ubiquitinated and phosphorylated, indicating protein misfolding and aggregation.
