What diseases are associated with NF-κB dysregulation?
Dysregulation of NF-κB is associated with several diseases, including:
Cancer: NF-κB promotes cell proliferation and survival, contributing to tumor growth and resistance to apoptosis. Autoimmune diseases: Aberrant NF-κB activation can lead to excessive immune responses, as seen in rheumatoid arthritis and lupus. Chronic inflammation: Persistent NF-κB activity is a hallmark of inflammatory diseases like Crohn's disease and ulcerative colitis. Neurodegenerative diseases: NF-κB has been implicated in the inflammatory responses seen in Alzheimer's disease and Parkinson's disease.
