Given its role in many diseases, NF-κB is an attractive target for therapeutic intervention. Strategies include:
Inhibitors of IκB kinase (IKK), which prevent the degradation of IκB and keep NF-κB inactive. Antioxidants that reduce oxidative stress and consequently inhibit NF-κB activation. Small molecules or peptides that directly inhibit NF-κB DNA-binding activity. Gene therapy approaches to modulate NF-κB activity at the genetic level.
