- Microcytic Anemia: If the MCV is less than 80 fl, it suggests that the RBCs are smaller than normal, which is often seen in iron deficiency anemia or thalassemia. - Macrocytic Anemia: If the MCV is greater than 100 fl, it indicates larger-than-normal RBCs, which can be associated with vitamin B12 or folate deficiency, liver disease, or hypothyroidism.