What Conditions are Associated with Dutcher Bodies?
Dutcher bodies are most commonly associated with multiple myeloma and Waldenström's macroglobulinemia. In multiple myeloma, plasma cells produce excessive amounts of a single type of immunoglobulin, leading to the formation of these intranuclear inclusions. In Waldenström's macroglobulinemia, there is an overproduction of IgM, which also leads to the formation of Dutcher bodies. These conditions are a subset of plasma cell dyscrasias, which involve abnormal plasma cell proliferation and immunoglobulin production.
