What Challenges Exist in Achieving Tissue Integration?
Several challenges can impede tissue integration. One significant challenge is the immune response, where the body may recognize foreign cells or materials as threats and initiate an immune reaction. Another challenge is the potential for fibrosis, where excessive ECM deposition can lead to scar tissue formation, disrupting normal tissue architecture and function. Additionally, achieving integration in tissue engineering applications can be complex, as it requires the precise coordination of multiple cell types and ECM components.
