In histological studies, SREBPs can be examined using various techniques such as immunohistochemistry (IHC), immunofluorescence, and Western blotting. These methods allow for the detection and localization of SREBPs within tissues. Additionally, gene expression analysis using techniques like quantitative PCR (qPCR) and RNA sequencing (RNA-seq) can provide insights into the regulatory roles of SREBPs in different physiological and pathological contexts.