The heart is primarily composed of three types of cells: cardiomyocytes, fibroblasts, and endothelial cells. Cardiomyocytes, the muscle cells of the heart, play a crucial role in contraction and force generation. During heart regeneration, these cells can proliferate and replace damaged tissue. Fibroblasts are involved in the formation of the extracellular matrix and can also influence the regenerative process. Endothelial cells line the blood vessels and are essential for revascularization of the regenerating tissue.
