What Histological Changes Occur During Heart Regeneration?
During heart regeneration, several histological changes are observed. Initially, there is an inflammatory response characterized by the infiltration of immune cells. This is followed by the proliferation of cardiomyocytes and other cell types, as well as the formation of new blood vessels through angiogenesis. The extracellular matrix undergoes remodeling to support the new tissue. In species with limited regenerative capacity, such as humans, fibroblasts often dominate the response, leading to the formation of scar tissue instead of functional myocardium.
