Several conditions can lead to decreased alveolar septa: - [Emphysema](href): A form of Chronic Obstructive Pulmonary Disease (COPD) characterized by the destruction of alveolar walls. - [Interstitial Lung Disease](href): A group of diseases causing scarring (fibrosis) of lung tissue, which can lead to the thinning and eventual loss of alveolar septa. - [Pulmonary Edema](href): Fluid accumulation in the alveoli can cause septal thickening, which may eventually lead to their destruction. - [Aging](href): Natural aging processes can lead to the gradual atrophy of alveolar septa.