What are the Structural Characteristics of the GAP Domain?
The GAP domain typically consists of conserved amino acid sequences that facilitate its binding to GTPases. The structure of the GAP domain is crucial for its function, as it must precisely interact with the GTPase to accelerate GTP hydrolysis. Crystal structures of various GAP domains have revealed that they often contain alpha-helices and beta-sheets that form a stable scaffold for interaction with the GTPase.
