What are the Pathological Implications of TGF α Dysregulation?
Dysregulation of TGF α expression and signaling can lead to various pathological conditions. Overexpression of TGF α has been implicated in the development and progression of several cancers, including breast cancer, lung cancer, and colorectal cancer. In these contexts, elevated levels of TGF α contribute to uncontrolled cell proliferation and tumor growth. Conversely, reduced TGF α activity can impair tissue repair and regeneration, leading to chronic wounds and other healing defects.
