What is the Role of TGF α in Cell Proliferation and Differentiation?
TGF α promotes cell proliferation by binding to EGFR, leading to the activation of the MAPK/ERK pathway and other signaling cascades. This results in the transcription of genes that drive the cell cycle forward. Additionally, TGF α influences cell differentiation by modulating the expression of specific genes that determine the fate of various cell types.
