What are the Pathological Conditions Associated with Fibroblast Proliferation?
Abnormal fibroblast proliferation can lead to several pathological conditions, including fibrosis and cancer. In fibrosis, excessive fibroblast activity results in the overproduction of extracellular matrix, leading to tissue scarring and organ dysfunction. In cancer, fibroblasts can contribute to the tumor microenvironment, supporting cancer cell growth and metastasis. Understanding the regulation of fibroblast proliferation is therefore crucial for developing therapeutic strategies for these conditions.
