What Are the Limitations of Histological Examination?
While histology is a valuable diagnostic tool, it has limitations. Artifacts introduced during tissue processing, such as shrinkage or distortion, can complicate interpretation. Sampling errors, where the biopsy does not capture the pathological area, can lead to false negatives. Additionally, some diseases may not show distinct histological changes, requiring molecular or genetic testing for diagnosis. Despite these limitations, histology remains a cornerstone of pathological diagnosis due to its ability to provide detailed insights into tissue architecture and cellular changes.
