Aging leads to several changes in the NMJ: - Decreased Number of Synaptic Vesicles: The number of synaptic vesicles containing acetylcholine decreases. - Fragmentation of the Postsynaptic Membrane: The postsynaptic membrane becomes more fragmented, reducing the efficiency of signal transmission. - Increased Synaptic Cleft Width: The synaptic cleft often widens with age, which can slow the diffusion of neurotransmitters.
