What are the Limitations and Challenges in Studying CD117?
Despite its importance, studying CD117 has several limitations and challenges. Some of these include:
Heterogeneity of Expression: CD117 expression can vary widely among different cell types and tumors, making it challenging to develop universal diagnostic and therapeutic strategies. Resistance to Therapy: Some tumors develop resistance to TKIs, necessitating the development of new therapeutic approaches. Technical Variability: Variations in immunohistochemical techniques and antibody specificity can affect the accuracy and reproducibility of CD117 detection.
