CD117 is associated with several medical conditions, both benign and malignant. Some of the key conditions include:
Gastrointestinal Stromal Tumors (GISTs): CD117 is highly expressed in GISTs, making it a valuable diagnostic marker for these tumors. Mastocytosis: Elevated levels of CD117 are found in mast cells in conditions like systemic mastocytosis and cutaneous mastocytosis. Acute Myeloid Leukemia (AML): CD117 is expressed in certain subtypes of AML, aiding in the diagnosis and classification of the disease. Melanoma: CD117 expression can be observed in some cases of melanoma, although it is less common.
