How do Cox Negative Fibers Relate to Mitochondrial Myopathies?
Mitochondrial myopathies are characterized by defects in the mitochondrial respiratory chain. The presence of COX negative fibers is a hallmark feature of these myopathies. These fibers typically present in a scattered or focal pattern within the muscle tissue, reflecting the heteroplasmic nature of mitochondrial DNA mutations. The analysis of COX negative fibers can help in diagnosing specific types of mitochondrial myopathies and understanding the extent of mitochondrial dysfunction.
