The presence of CYP2C19 in tissues can be detected using various histological techniques. Immunohistochemistry (IHC) is commonly used to localize the enzyme within tissue sections. In IHC, antibodies specific to CYP2C19 are applied to the tissue, where they bind to the enzyme. The bound antibodies are then visualized using a secondary antibody conjugated to a detectable marker, such as a fluorescent dye or an enzyme that catalyzes a color-producing reaction.
