What are the Histological Features of PTEN-Related Conditions?
Histologically, PTEN-related conditions may present with a variety of features depending on the tissue and type of condition. In breast cancer, for example, loss of PTEN expression can lead to increased cell proliferation, evident through higher mitotic indices and disrupted tissue architecture. In endometrial cancer, PTEN mutations are often associated with endometrioid histology and glandular crowding.