What are the Cellular Changes in Acute Tubular Necrosis?
In Acute Tubular Necrosis, the tubular epithelial cells undergo necrosis, which is evident by the loss of nuclear staining and cytoplasmic fragmentation. The affected cells slough off into the tubular lumen, leading to obstruction and further compromise of renal function. Additionally, the basement membrane may be disrupted, hampering the regenerative capacity of the tubules.
