What are the Histological Features of Cardiomyopathy?
Histological examination of cardiomyopathies reveals several key features:
Myocyte Hypertrophy: Enlarged cardiomyocytes with boxcar nuclei, often seen in DCM and HCM. Fibrosis: Increased interstitial and replacement fibrosis is common, particularly in DCM, HCM, and RCM. Myocyte Disarray: Disorganized arrangement of myocytes and sarcomeres, primarily observed in HCM. Fibrofatty Replacement: Replacement of myocytes with fibrous and fatty tissue, characteristic of ARVC. Infiltrative Processes: Presence of amyloid, sarcoid granulomas, or other infiltrative materials in RCM.
