What are the Challenges in Histological Diagnosis?

Diagnosing cardiomyopathies through histology can present several challenges:

Sample Size and Location: The affected myocardium may be patchy, and obtaining a representative sample can be difficult.
Subtle Changes: Early or mild forms of cardiomyopathy may exhibit only subtle histological changes, making diagnosis challenging without advanced imaging techniques.
Overlap with Other Diseases: Histological features of cardiomyopathies can overlap with other cardiac conditions, such as myocarditis or ischemic heart disease, complicating the diagnostic process.