What are Some Histological Differentiators Among Myopathies?
Different myopathies exhibit unique histological features that aid in their differentiation:
Duchenne Muscular Dystrophy: Characterized by extensive muscle fiber necrosis, regeneration, and replacement of muscle tissue with fat and connective tissue. Myotonic Dystrophy: Features include central nuclei within muscle fibers and ring fibers. Polymyositis: Marked by endomysial inflammatory infiltrates and muscle fiber necrosis. Dermatomyositis: Identified by perivascular inflammatory infiltrates and perifascicular atrophy. Inclusion Body Myositis: Characterized by rimmed vacuoles, amyloid deposits, and endomysial inflammation.
