What are Some Histological Differentiators Among Myopathies?

Different myopathies exhibit unique histological features that aid in their differentiation:

Duchenne Muscular Dystrophy: Characterized by extensive muscle fiber necrosis, regeneration, and replacement of muscle tissue with fat and connective tissue.
Myotonic Dystrophy: Features include central nuclei within muscle fibers and ring fibers.
Polymyositis: Marked by endomysial inflammatory infiltrates and muscle fiber necrosis.
Dermatomyositis: Identified by perivascular inflammatory infiltrates and perifascicular atrophy.
Inclusion Body Myositis: Characterized by rimmed vacuoles, amyloid deposits, and endomysial inflammation.