What are the Functions of Mature TGF-β in Histology?
Mature TGF-β has diverse roles in histological contexts:
1. Cell Proliferation and Differentiation: TGF-β can either promote or inhibit cell proliferation, depending on the cell type. It also induces differentiation in various cell lineages. 2. Extracellular Matrix (ECM) Production: TGF-β stimulates the production of ECM components such as collagen and fibronectin, crucial for tissue architecture and wound healing. 3. Immunoregulation: TGF-β is involved in immune tolerance and regulation, suppressing immune responses and promoting regulatory T cell development. 4. Apoptosis: TGF-β can induce apoptosis in certain cell types, contributing to tissue homeostasis and development.
