The primary function of alpha secretase is to cleave membrane proteins, thereby regulating their function and turnover. In the context of APP, alpha secretase cleavage prevents the formation of toxic amyloid-beta peptides. This activity is part of the non-amyloidogenic pathway of APP processing. Additionally, alpha secretase is involved in the shedding of cell surface receptors and the release of signaling molecules, which are crucial for cell communication and signaling pathways.
