What are the Pathological Implications of Nitric Oxide?
While nitric oxide has many beneficial effects, its overproduction can lead to pathological conditions. Excessive nitric oxide can react with superoxide to form peroxynitrite, a potent oxidant that can cause cellular damage. Inflammatory conditions often see upregulated iNOS expression, which can lead to tissue damage and contribute to diseases such as rheumatoid arthritis and septic shock.
