What are the Clinical Implications of ZIC3 Mutations?
Mutations in the ZIC3 gene are associated with several congenital disorders. One such disorder is X-linked heterotaxy, a condition characterized by the abnormal arrangement of internal organs. Patients with ZIC3 mutations may also present with congenital heart defects, such as atrial and ventricular septal defects. Understanding the molecular mechanisms of ZIC3 and its role in development is crucial for developing potential therapeutic strategies for these conditions.
