What Are the Clinical Implications of UPP Dysfunction?
Dysfunction in the UPP can lead to a variety of diseases. For instance, defects in ubiquitin ligases are associated with certain types of cancer, whereas impaired proteasome activity is linked to neurodegenerative diseases like Parkinson's and Alzheimer's. Understanding the UPP at the histological level can aid in the development of targeted therapies for these conditions.
