Dysregulation of profilin is implicated in various diseases:
Cancer: Altered profilin expression is associated with tumor cell migration and metastasis in certain cancers. Neurodegenerative Diseases: Mutations in profilin can lead to neurodegenerative disorders such as Amyotrophic Lateral Sclerosis (ALS). Cardiovascular Diseases: Profilin plays a role in maintaining the structural integrity of cardiomyocytes, implicating it in heart diseases. Allergies: Profilin is a known allergen in pollen, causing allergic reactions in sensitized individuals.
