Profilin activity is regulated through various mechanisms:
Phosphorylation: Profilin can be phosphorylated on specific residues, altering its affinity for actin and other binding partners. Interactions: Profilin binds to proteins such as formin, VASP, and WASP, which regulate actin nucleation and elongation. Localization: Profilin's localization within the cell is tightly controlled, often concentrating in areas with active actin remodeling.
